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    Population genetic structure and cladistic analysis of Trypanosoma brucei isolates

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    Authors
    Agbo, E.C.
    Clausen, P.H.
    Buscher, P.
    Majiwa, P.A.O.
    Claassen, E.
    Marinus, F.W.P.
    Date
    2003
    Language
    en
    Type
    Journal Article
    Accessibility
    Limited Access
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    Citation
    Infection, Genetics and Evolution;3(3): 165-174
    Permanent link to cite or share this item: http://hdl.handle.net/10568/28769
    DOI: https://dx.doi.org/10.1016/S1567-1348(03)00071-6
    Abstract/Description
    Using a novel multilocus DNA marker analysis method, we studied the population genetic structure of Trypansoma brucei stocks and derived clones isolated from animal and rhodesiense sleeping sickness patients during a national sleeping sickness control program in Mukono district, Uganda. We then performed a cladistic analysis to trace relationships and evolution, using stocks and clones recovered from geographically and temporally matched hosts, including inter-strain comparisons with T. b. gambiense stocks and clones. Our results show that while there was close genetic relatedness among parasite populations from the same geographical region, micro-heterogeneities exist between different stocks. Data are presented that indicate that not every human sleeping sickness focus may be associated with a particular human-infective trypanosome strain responsible for long-term stability of the reference focus. We provide evidence of genetic sub-structuring among type 1 T. b. gambiense stocks, which has potentially important implications for molecular epidemiology of T. brucei.
    AGROVOC Keywords
    TRYPANOSOMA BRUCEI; POPULATION GENETICS; DNA; GENETIC MARKERS; ANIMALS; MANKIND; TRYPANOSOMA GAMBIENS; TRYPANOSOMIASIS; EPIDEMIOLOGY
    Subjects
    EPIDEMIOLOGY; GENETICS;
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    • ILRI archive [4979]
    • ILRI articles in journals [4809]

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