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dc.contributor.authorNaessens, Jan
dc.contributor.authorKitani, H.
dc.contributor.authorMomotani, E.
dc.contributor.authorSekikawa, K.
dc.contributor.authorNthale, J.M.
dc.contributor.authorIraqi, F.A.
dc.date.accessioned2013-06-11T09:25:39Z
dc.date.available2013-06-11T09:25:39Z
dc.date.issued2004
dc.identifier.citationActa Tropica;92(3): 193-203
dc.identifier.issn0001-706X
dc.identifier.urihttp://hdl.handle.net/10568/29973
dc.description.abstractC57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-alpha) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-alpha genes was correlated with the capacity to control parasitaemia and with survival time. Absence of TNF-alpha resulted in a diminished capacity to form germinal centres in lymph nodes and spleen. Since germinal centres are involved in antibody production and affinity maturation, the susceptibility of the TNF-alpha-deficient mice could have been due to this secondary defect. Despite the lack of the germinal centres, the antibody responses to internal and exposed trypanosome antigens and to non-trypanosome antigens were not significantly different. Also the relative avidities measured in infected sera did not significantly differ between the two mouse strains. These data suggest that the role of TNF-alpha in control of T. congolense was not due to its role in the development of an antibody response.
dc.language.isoen
dc.sourceActa Tropica
dc.subjectTRYPANOSOMA CONGOLENSE
dc.subjectDISEASE RESISTANCE
dc.subjectANTIBODIES
dc.subjectCYTOKINES
dc.titleSusceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response
dc.typeJournal Article
cg.subject.ilriANIMAL DISEASES
cg.subject.ilriDISEASE CONTROL
cg.subject.ilriLIVESTOCK
cg.identifier.statusRestricted Access
cg.identifier.doihttps://dx.doi.org/10.1016/j.actatropica.2004.05.015
cg.creator.idJan Naessens: 0000-0002-7075-9915


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