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dc.contributor.authorBehnke, J.M.
dc.contributor.authorMenge, D.M.
dc.contributor.authorNagda, S.
dc.contributor.authorNoyes, H.
dc.contributor.authorIraqi, F.A.
dc.contributor.authorKemp, Stephen J.
dc.contributor.authorMugambi, R.J.M.
dc.contributor.authorBaker, R.L.
dc.contributor.authorWakelin, D.
dc.contributor.authorGibson, John P.
dc.date.accessioned2010-01-05T18:20:16Z
dc.date.available2010-01-05T18:20:16Z
dc.date.issued2010-02-15
dc.identifier.citationBehnke, J.M.; Menge, D.M.; Nagda, S.; Noyes, H.; Iraqi, F.A.; Kemp, S.J.; Mugambi, R.J.M.; Baker, R.L.; Wakelin, D.; Gibson, J.P. 2010. Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice. Parasitology. 137(2): 311-320en_US
dc.identifier.urihttp://hdl.handle.net/10568/358
dc.descriptionD.M. Menge, S. Nagda, F.A. Iraqi, R.J.M. Mugambi & J.P. Gibson are ILRI authorsen_US
dc.description.abstractA comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.en_US
dc.language.isoenen_US
dc.sourceParasitologyen_US
dc.subjectDISEASE RESISTANCEen_US
dc.titleQuantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of miceen_US
dc.typeJournal Articleen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.identifier.statusLimited Accessen_US
cg.identifier.doihttps://dx.doi.org/10.1017/S0031182009991028en_US


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