Show simple item record

dc.contributor.authorKopp, N.
dc.contributor.authorDiaz, D.
dc.contributor.authorAmacker, M.
dc.contributor.authorOdongo, David O.
dc.contributor.authorBeier, K.
dc.contributor.authorNitsch, C.
dc.contributor.authorBishop, Richard P.
dc.contributor.authorDaubenberger, C.A.
dc.date.accessioned2010-01-12T05:47:34Z
dc.date.available2010-01-12T05:47:34Z
dc.date.issued2009-12-10
dc.identifier.citationKopp, N.; Diaz, D.; Amacker, M.; Odongo, D.O.; Beier, K.; Nitsch, C.; Bishop, R.P.; Daubenberger, C.A. 2009. Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues Vaccine. v. 28(1). p. 261-269.en_US
dc.identifier.urihttp://hdl.handle.net/10568/381
dc.descriptionDavid O. Odongo and Richard P. Bishop are ILRI authorsen_US
dc.description.abstractThe BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vaccines by induction of high levels of tick gut binding antibodies that are also cross-reactive with a range of BM86 homologues expressed in other important tick species. Here we have used a BD86 derived synthetic peptide, BD86-3, to raise a series of mouse monoclonal antibodies. One of these mAbs, named 12.1, recognized BM86 homologues in immuno-histochemical analyses in four out of five tick species including R. (B.) microplus, Rhipicephalus (Boophilus) decoloratus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus. Our results indicate that broadly cross-reactive tick gut binding antibodies can be induced after immunization with a synthetic peptide derived from the protein BD86.en_US
dc.language.isoenen_US
dc.sourceVaccineen_US
dc.titleIdentification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologuesen_US
dc.typeJournal Articleen_US
cg.subject.ilriVACCINESen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.identifier.doihttps://dx.doi.org/10.1016/j.vaccine.2009.09.085en_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record