Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation
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Gomes, H., Moraes, J., Githaka, N., Martins, R., Isezaki, M., Silva Vaz, I. da Jr., Logullo, C., Konnai, S. and Ohashi, K. 2015. Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation. Veterinary Parasitology 211(3-4):266–273.
Permanent link to this item: http://hdl.handle.net/10568/67120
Among arthropods, ticks lead as vectors of animal diseases and rank second to mosquitoes in transmitting human pathogens. Cyclin-dependent kinases (CDK) participate in cell cycle control in eukaryotes. CDKs are serine/threonine protein kinases and these catalytic subunits are activated or inactivated at specific stages of the cell cycle. To determine the potential of using CDKs as anti-tick vaccine antigens, hamsters were immunized with recombinant Ixodes persulcatus CDK10, followed by a homologous tick challenge. Though it was not exactly unexpected, IpCDK10 vaccination significantly impaired tick blood feeding and fecundity, which manifested as low engorgement weights, poor oviposition, and a reduction in 80% of hatching rates. These findings may underpin the development of more efficacious anti-tick vaccines based on the targeting of cell cycle control proteins.