CGSpaceA Repository of Agricultural Research Outputs
    View Item 
    •   CGSpace Home
    • International Institute of Tropical Agriculture (IITA)
    • IITA Journal Articles
    • View Item
       
    • CGSpace Home
    • International Institute of Tropical Agriculture (IITA)
    • IITA Journal Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Insertion/deletion polymorphism of the angiotensinconverting enzyme gene and the risk of hypertension among residents of two cities, SouthSouth Nigeria

    Thumbnail
    View/Open
    U14ArtKooffrehInsertionNothomDev.pdf (327.4Kb)
    
    Authors
    Kooffreh, M.E.
    Anumudu, C.I.
    Kumar, P.L.
    Date
    2014
    Language
    en
    Type
    Journal Article
    Review status
    Peer Review
    Accessibility
    Open Access
    Metadata
    Show full item record
    Share
    Citation
    Kooffreh, M. E., Anumudu, C. I. & Kumar, P. L. (2014). Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and the risk of hypertension among residents of two cities, South-South Nigeria. Advanced biomedical research, 3.
    Permanent link to cite or share this item: http://hdl.handle.net/10568/76088
    DOI: https://dx.doi.org/10.4103/2277-9175.133184
    Abstract/Description
    Background: Hypertension is a public health challenge due to its high prevalence, and is a major risk factor for cardiovascular diseases. This study was designed to determine the frequency of the I/D polymorphism of the angiotensin-converting enzyme gene and its association with hypertension in a sample population of Calabar and Uyo, South-South Nigeria. Materials and Methods: A population-based case control design consisting of total of 1224 participants, 612 each of patients and controls, were randomly recruited from hypertension clinics and the general population. The I/D polymorphism was investigated using polymerase chain reaction. Multiple regression and odds ratio (OR) was applied to test whether the ID genotypes were predictors of hypertension. Results: The I/D genotype frequencies were 73(12%), 262(43%) and 277(45%); 74(12%), 303(50%) and 235(38%) for the II, ID, DD genotype in patient and control groups, respectively. A higher frequency of the ID genotype was observed in controls of which 208(61%) were females. By multiple regression analysis, age was a predictor for SBP in patients, r = 0.596, and DBP in controls, r = 0.555. Gender, Body mass index, I/D genotypes were not significant predictors for hypertension but the I/D polymorpism was associated with an increased risk for hypertension with an OR of 1.15 95%CI (0.924-1.456). Conclusion: The I/D polymorphism of the angiotensin-converting enzyme gene was a risk factor for hypertension in the sample population of Calabar and Uyo. This research will form baseline information for subsequent molecular studies in this population. Key Words: Angiotensin-converting enzyme gene, frequency
    AGROVOC Keywords
    ANGIOTENSIN; HYPERTENSION; GENOTYPE; POLYMORPHISM
    Countries
    NIGERIA
    Regions
    AFRICA; WEST AFRICA
    Collections
    • IITA Journal Articles [1807]

    AboutPrivacy policySend Feedback
     

    My Account

    LoginRegister

    Browse

    All of CGSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesBy AGROVOC keywordBy ILRI subjectBy CPWF subjectBy CCAFS subjectBy CIFOR subjectBy IWMI subjectBy RegionBy CountryBy SubregionBy CRP subjectBy River basinBy Output typeBy CTA subjectBy WLE subjectBy Bioversity subjectBy CIAT subjectBy CIP subjectBy animal breedBy CGIAR System subjectThis CollectionBy Issue DateAuthorsTitlesBy AGROVOC keywordBy ILRI subjectBy CPWF subjectBy CCAFS subjectBy CIFOR subjectBy IWMI subjectBy RegionBy CountryBy SubregionBy CRP subjectBy River basinBy Output typeBy CTA subjectBy WLE subjectBy Bioversity subjectBy CIAT subjectBy CIP subjectBy animal breedBy CGIAR System subject

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    AboutPrivacy policySend Feedback