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dc.contributor.authorGichohi-Wainaina, Wanjiku N.
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorTowers, G. Wayne
dc.contributor.authorVerhoef, Hans
dc.contributor.authorVeenemans, Jacobien
dc.contributor.authorTalsma, Elise
dc.contributor.authorHarryvan, Jan
dc.contributor.authorBoekschoten, Mark V.
dc.contributor.authorFeskens, Edith J.
dc.contributor.authorMelse-Boonstra, Alida
dc.date.accessioned2016-07-22T23:14:58Z
dc.date.available2016-07-22T23:14:58Z
dc.date.issued2016-06-22
dc.identifier.citationGichohi-Wainaina, Wanjiku N.; Tanaka, Toshiko; Towers, G. Wayne; Verhoef, Hans; Veenemans, Jacobien; Talsma, Elise; Harryvan, Jan; Boekschoten, Mark V.; Feskens, Edith J.; Melse-Boonstra, Alida. 2016. Associations between common variants in iron-related genes with haematological traits in populations of African ancestry . PLoS ONE 11(6): e0157996.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10568/76253
dc.description.abstractBackground Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African ancestry populations. Methods We tested the associations of 20 previously identified iron status-associated single nucleotide polymorphisms (SNPs) in 628 Kenyans, 609 Tanzanians, 608 South Africans and 228 African Americans. In each study, we examined the associations present between 20 SNPs with ferritin and haemoglobin, adjusting for age, sex and CRP levels. Results In the meta analysis including all 4 African ancestry cohorts, we replicated previously reported associations with lowered haemoglobin concentrations for rs2413450 (β = -0.19, P = 0.02) and rs4820268 (β = -0.16, P = 0.04) in TMPRSS6. An association with increased ferritin concentrations was also confirmed for rs1867504 in TF (β = 1.04, P = <0.0001) in the meta analysis including the African cohorts only. Conclusions In all meta analyses, we only replicated 4 of the 20 single nucleotide polymorphisms reported to be associated with iron status in large GWA studies of European ancestry individuals. While there is now evidence for the associations of a number of genetic variants with iron status in both European and African ancestry populations, the considerable lack of concordance highlights the importance of continued ancestry-specific studies to elucidate the genetic underpinnings of iron status in ethnically diverse populations.en_US
dc.format.extent11(6): e0157996en_US
dc.language.isoenen_US
dc.sourcePLOS ONEen_US
dc.subjectFERRITINen_US
dc.subjectGENOTYPESen_US
dc.subjectDEFICIENCIESen_US
dc.subjectIRONen_US
dc.subjectINFLAMMATIONen_US
dc.subjectPOPULATION GENETICSen_US
dc.subjectGENOMICSen_US
dc.subjectFERRITÍNen_US
dc.subjectGENOTIPOSen_US
dc.subjectHIERROen_US
dc.subjectINFLAMACIÓNen_US
dc.subjectGENÉTICA DE POBLACIONESen_US
dc.subjectGENÓMICAen_US
dc.titleAssociations between common variants in iron-related genes with haematological traits in populations of African ancestryen_US
dc.description.versionPeer Reviewen_US
dc.typeJournal Articleen_US
cg.subject.ciatNUTRITIONen_US
cg.identifier.statusOpen Accessen_US
cg.identifier.doihttps://dx.doi.org/10.1371/journal.pone.0157996en_US
cg.isijournalISI Journalen_US
cg.coverage.regionAFRICAen_US
cg.coverage.regionEAST AFRICAen_US


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