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    Expression profile of Rhipicephalus microplus vitellogenin receptor during oogenesis

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    Authors
    Seixas, A.
    Alzugaray, M.F.
    Tirloni, T.
    Parizi, L.F.
    Pinto, A.F.M.
    Githaka, Naftaly W.
    Konnai, S.
    Ohashi, K.
    Yates, J.R.
    Termignoni, C.
    Silva Vaz, I. da
    Date
    2018-01
    Language
    en
    Type
    Journal Article
    Review status
    Peer Review
    ISI journal
    Accessibility
    Limited Access
    Usage rights
    Copyrighted; all rights reserved
    Metadata
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    Citation
    Seixas, A., Alzugaray, M.F., Tirloni, T., Parizi, L.F., Pinto, A.F.M., Githaka, N.W., Konnai, S., Ohashi, K., Yates, J.R., III, Termignoni, C. and Silva Vaz Jr., I. da. 2018. Expression profile of Rhipicephalus microplus vitellogenin receptor during oogenesis. Ticks and Tick-borne Diseases 9(1): 72–81.
    Permanent link to cite or share this item: https://hdl.handle.net/10568/89178
    DOI: https://doi.org/10.1016/j.ttbdis.2017.10.006
    Abstract/Description
    The vitellogenin receptor (VgR), which belongs to the low-density lipoprotein receptors(LDLR) family, regulates the absorption of yolk protein accumulated in developing oocytes during oogenesis. In the present study, the full sequence of Rhipicephalus microplus VgR (RmVgR) and the partial sequence of Rhipicephalus appendiculatus VgR (RaVgR) ORF were determined and cloned. The RmVgR amino acid sequence contains the five highly conserved structural motifs characteristic of LDLR superfamily members, the same overall structure as observed in other species. Phylogenetic analysis separated VgRs in two major groups, corresponding to receptors from acarines and insects. Consistent with observations from other arthropods, RmVgR was specifically expressed in the ovarian tissue and its peak of expression occurs in females that are detaching from the host. Silencing with RmVgR dsRNA reduced VgR expression, which resulted in reduced fertility, evidenced by a decrease in the number of larvae. The present study confirms RmVgR is a specific receptor involved in yolk protein uptake and oocyte maturation in R. microplus, playing an important role in tick reproduction.
    CGIAR Author ORCID iDs
    Naftaly Githakahttps://orcid.org/0000-0003-4530-7164
    CGIAR Affiliations
    Livestock
    AGROVOC Keywords
    oogenesis; ova; rhipicephalus; vitellogenins
    Subjects
    REPRODUCTION; RESEARCH;
    Investors/sponsors
    Japanese Society for the Promotion of Science; National Institute of General Medical Sciences, United States
    Collections
    • CRP Livestock health flagship [174]
    • CRP Livestock journal articles [670]
    • ILRI animal and human health program outputs [1188]
    • ILRI articles in journals [5969]
    • ILRI Tick unit [45]

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